Beyond the Jab Part 2: Supportive Supplements for GLP-1 Medication Use

GLP-1 medications such as Ozempic, Wegovy and Saxenda are becoming increasingly common for weight loss, diabetes and metabolic health. They can be very effective at slowing digestion, reducing appetite and aiding blood glucose regulation. However, this often comes with side effects such as fatigue, muscle loss, and digestive symptoms such as nausea, bloating, and constipation.

Eating reduced amounts can lead to deficiencies, as your body still requires nutrients, protein, and digestive support. Carefully chosen supplements, guided by a qualified practitioner, can help support your body while the medication does its job. Here are some general recommendations.

1. Multivitamin: Filling the nutrient gaps

Because GLP-1 medications reduce appetite, many people unintentionally eat less variety and fewer nutrients. Over time, this will lead to nutrient deficiencies.

A good-quality multivitamin can help support:

• Energy levels with B vitamins

• Immune health with vitamins A, C, and zinc

• Thyroid and metabolic function with iodine and selenium

Research shows that calorie-restricted diets, particularly those with rapid weight loss, increase the risk of micronutrient deficiencies, especially vitamin D, C, iron, selenium and zinc (Damms-Machado A, et al., 2012).

Naturopathic tip: Look for a multivitamin with bioavailable forms of nutrients and gentle dosing to avoid worsening nausea.

2. Digestive enzymes: Helping with bloating & heaviness

GLP-1 medications slow stomach emptying. While this helps with fullness and blood sugar control, it can also cause:

• Bloating

• Indigestion

• Feeling uncomfortably full after small meals

Digestive enzymes help break down food more efficiently, making meals easier to tolerate.

3. Fibre: Supporting gut health & bowel regulation

Constipation is one of the most common side effects of GLP-1 use. Fibre helps by:

• Supporting regular bowel movements

• Feeding beneficial gut bacteria

• Assisting blood sugar balance

Gentle options include:

• Psyllium husk

• Partially hydrolysed guar gum (PHGG)

• Acacia fibre

Naturopathic tip: Start with small amounts and increase slowly to avoid gas or bloating.

4. Protein powder: Protecting muscle while losing weight

When appetite drops, protein intake often drops too, which can increase the risk of:

• Muscle loss

• Fatigue

• Slower metabolism

Protein powders provide an easy, low-volume way to meet daily needs when full meals feel challenging.

Adequate protein intake during weight loss helps preserve lean muscle mass and supports metabolic health.

Options may include:

• Whey (if tolerated) or collagen

• Plant-based blends for dairy-free clients

5. Magnesium: For constipation, sleep & stress

Magnesium plays a role in:

• Energy

• Bowel regularity

• Muscle relaxation

• Nervous system support

• Sleep quality

Many people already have low magnesium intake, and reduced food intake may worsen the deficiency of this mineral.

Best forms: Magnesium glycinate is well-absorbed, gentle, and calming. Magnesium citrate is more bowel-stimulating. Optimal dosage and form may differ between individuals.

6. Iron: Only when needed

Reduced intake of iron-rich foods (like red meat) can increase the risk of low iron, especially in menstruating women.

Symptoms may include:

• Fatigue

• Weakness

• Dizziness

Iron deficiency is common during energy-restricted diets, but excess iron supplementation may increase gastrointestinal side effects. Therefore, it is best to have your iron level tested by your practitioner. Natural supplemental forms of iron have fewer side effects than many pharmaceutical brands, so make sure you choose one that’s gentle on digestion.

7. Slippery Elm: Gentle support for nausea & reflux

Slippery elm is a traditional herbal medicine that helps soothe the lining of the digestive tract.

It may help relieve:

• Nausea

• Reflux

• Upper digestive discomfort

Slippery elm forms a soothing gel (mucilage) that coats and protects irritated tissues.

Tip: Take away from medications, as it may slow absorption.

8. Probiotics: Supporting the gut microbiome

Changes in eating patterns, digestion, and bowel habits can affect the balance of gut bacteria.

Probiotics may help:

• Improve digestive comfort

• Support regular bowel movements

• Support immune and metabolic health

Emerging research shows that the gut microbiota plays an essential role in metabolic regulation and in the response to GLP-1 therapies (Trapanese V, et al., 2025). Speak with your practitioner to check which strains are best for you.

A whole-body approach matters

Supplements work best when combined with:

• Adequate hydration

• Small, balanced meals

• Gentle movement to support digestion

• Regular monitoring of nutrient status

Every person responds differently to GLP-1 medications, which is why individualised naturopathic support is key.

Final thoughts

GLP-1 medications can be life-changing, but they also change how your body digests, absorbs, and uses nutrients. The right supplements can help reduce side effects, protect nutritional status, and support long-term wellbeing, especially when tailored to your unique needs.

References:

Damms-Machado A, et al. Micronutrient deficiency in obese subjects undergoing low calorie diet. Nutr J. 2012 Jun 1;11:34. doi: 10.1186/1475-2891-11-34. 

Trapanese V, et al. Bidirectional Interactions Between the Gut Microbiota and Incretin-Based Therapies. Life, 2025 May 15(6), 843.